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Additional investigations are required to determine whether each miRNA reflects the cause or effect of metformin treatment

Statistics and reproducibility Statistical significance was calculated with R project ( Multiple comparisons were performed using a one-way ANOVA test with post hoc Tukey test, unless stated otherwise

Of the 60 voluntary participants in this study, those who took hyaluronic acid showed a significant reduction in the depth and length of the wrinkles, compared to those who took placebo as established by microscopic examinations

3D), as indicated by the white appearance of the merged macrophage, neutrophil, and bacterial fluorescent channels (see Supplementary Fig